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GPA 512

CAS No. 1808115-35-6

GPA 512( GPA512 | GPA-512 )

Catalog No. M12766 CAS No. 1808115-35-6

The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GPA 512
  • Note
    Research use only, not for human use.
  • Brief Description
    The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
  • Description
    The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes; increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone; significantly reduces tumor growth in DU145 xenograft tumors.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GPA512 | GPA-512
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1808115-35-6
  • Formula Weight
    371.448
  • Molecular Formula
    C17H25NO6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@H]1C[C@@H](CC[C@H]2OC3=O)[C@]2(O)C3[C@@H]1SC[C@H](NC(C)=O)C(OC)=O
  • Chemical Name
    methyl N-acetyl-S-((2aR,2a1S,4aR,6S,7R,7aS)-2a1-hydroxy-6-methyl-1-oxodecahydroindeno[1,7-bc]furan-7-yl)-L-cysteinate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Escobar Z, et al. J Med Chem. 2016 May 26;59(10):4551-62.
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