Cart
sales@molnova.com
GPA 512
CAS No. 1808115-35-6
GPA 512 ( GPA512;GPA-512 )
Catalog No. M12766 CAS No. 1808115-35-6
The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGPA 512
-
NoteResearch use only, not for human use.
-
Brief DescriptionThe orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
-
DescriptionThe orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes; increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone; significantly reduces tumor growth in DU145 xenograft tumors.
-
SynonymsGPA512;GPA-512
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1808115-35-6
-
Formula Weight371.45
-
Molecular FormulaC17H25NO6S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC[C@H]1C[C@@H](CC[C@H]2OC3=O)[C@]2(O)C3[C@@H]1SC[C@H](NC(C)=O)C(OC)=O
-
Chemical Namemethyl N-acetyl-S-((2aR,2a1S,4aR,6S,7R,7aS)-2a1-hydroxy-6-methyl-1-oxodecahydroindeno[1,7-bc]furan-7-yl)-L-cysteinate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Escobar Z, et al. J Med Chem. 2016 May 26;59(10):4551-62.
molnova catalog
related products
-
(R)-Lisofylline
(R)-Lisofylline is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 μM).
-
Stattic
Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
-
Hispidol
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
